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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLK4
All Species:
13.64
Human Site:
S298
Identified Species:
30
UniProt:
O00444
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00444
NP_055079.3
970
108972
S298
S
T
A
I
T
A
S
S
S
T
S
I
S
G
S
Chimpanzee
Pan troglodytes
XP_517431
973
109258
S298
S
T
A
I
T
A
S
S
S
T
S
I
S
G
S
Rhesus Macaque
Macaca mulatta
XP_001105577
970
108780
S298
S
T
A
I
T
A
S
S
S
T
S
I
S
G
S
Dog
Lupus familis
XP_533295
969
109039
S298
S
T
A
I
T
A
S
S
S
T
S
I
S
G
S
Cat
Felis silvestris
Mouse
Mus musculus
Q64702
925
103728
V259
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
Rat
Rattus norvegicus
B2GUY1
924
103752
V259
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516165
519
56295
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6PAD2
944
105622
V279
Q
S
K
V
M
G
A
V
E
D
S
M
D
S
G
Zebra Danio
Brachydanio rerio
Q7ZVS3
940
103466
D275
S
G
P
T
A
S
K
D
S
G
S
S
N
G
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O97143
769
85869
N104
G
E
L
H
R
Y
M
N
H
I
A
R
P
F
T
Honey Bee
Apis mellifera
XP_623133
730
82506
A65
D
R
V
H
Q
E
V
A
I
H
S
K
L
K
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
97.3
88.7
N.A.
78.8
78.9
N.A.
30.6
N.A.
60.3
52.1
N.A.
28.9
35
N.A.
N.A.
Protein Similarity:
100
99.3
98.8
93.7
N.A.
86.9
86.5
N.A.
40.4
N.A.
74.1
67.1
N.A.
45.2
50.7
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
13.3
13.3
N.A.
0
N.A.
6.6
26.6
N.A.
0
6.6
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
20
20
N.A.
0
N.A.
33.3
40
N.A.
20
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
37
0
10
37
10
10
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
28
0
0
0
0
0
0
10
0
28
0
0
10
0
0
% D
% Glu:
0
10
0
0
0
10
0
0
10
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
19
10
0
% F
% Gly:
10
10
0
0
0
10
0
0
0
10
0
0
0
46
19
% G
% His:
0
0
0
19
0
0
0
0
10
10
19
0
0
0
0
% H
% Ile:
0
0
0
37
0
0
0
0
10
10
0
37
0
0
0
% I
% Lys:
0
0
10
0
0
0
10
0
0
0
0
10
0
10
0
% K
% Leu:
0
0
28
0
19
0
0
0
19
0
0
0
10
0
0
% L
% Met:
0
0
0
0
10
0
10
0
0
0
0
10
0
19
0
% M
% Asn:
0
0
0
0
0
0
0
10
0
0
0
0
10
0
10
% N
% Pro:
0
0
10
0
0
0
0
0
0
0
0
19
10
0
0
% P
% Gln:
10
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
28
0
0
10
0
0
0
0
0
0
10
0
0
0
% R
% Ser:
46
10
0
19
0
28
55
37
46
0
64
10
37
10
55
% S
% Thr:
0
37
0
10
37
0
0
0
0
37
0
0
0
0
10
% T
% Val:
0
0
10
10
0
0
10
28
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _